In this study, the effect of dopamine as agonist dopaminergic receptor and alpha and beta adrenergic receptor \r\nwas studied both in vivo. The effect of tolazoline as an antagonist of alpha-2 adrenergic receptor was also studied \r\nin patients with bronchial asthma and persons with increased bronchial reactibility. Parameters of the lung function \r\nare determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. \r\nAerosolization is done with standard aerosolizing machines ââ?¬â?? Asema. Results gained in vivo shows that stimulation \r\nof alpha adrenergic receptor with dopamine (4 Ã?µg and 300 Ã?µg) causes significant contraction (p > 0.1) of the smooth \r\nbronchial musculature. Whereas, blockage of alpha-2 adrenergic receptor with tolazoline (20 mg by inhalator ways) \r\ndoes not change the bronchimotor tonus significantly (p>0.1) when compared to the stimulation of beta-2 adrenergic \r\nreceptor with hexoprenaline (2 inh. x 0.2 mg) and blocker of cholinergic receptor - ipratropium (2 inh. x 1 mg). Reaction \r\nof the smooth musculature to dopamine suggests that this substance may cause constriction through alpha adrenergic \r\nreceptors. Reaction may also be intermediated in indirect ways through dopaminergic receptor of the cholinergic \r\ntransmission, with intracellular inhibition of the creation of cAMP.
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